GeV {\gamma}-ray Emission Detected by Fermi-LAT Probably Associated with the Thermal Composite Supernova Remnant Kesteven 41 in a Molecular Environment

Hadron emission from supernova remnant (SNR)-molecular cloud (MC) association systems has been widely regarded as a probe of the shock-accelerated cosmic-ray protons. Here, we report on the detection of a {\gamma}-ray emission source, with a significance of 24{\sigma} in 0.2-300 GeV, projected to lie to the northwest of the thermal composite SNR Kesteven 41, using 5.6 years of Fermi-Large Area Telescope (LAT) observation data. No significant long-term variability in the energy range 0.2--300 GeV is detected around this source. The 3{\sigma} error circle, 0.09 degree; in radius, covers the 1720MHz OH maser and is essentially consistent with the location of the V_{LSR} ~-50 km/s MC with which the SNR interacts. The source emission has an exponential cutoff power-law spectrum with a photon index of 1.9+/-0.1 and a cutoff energy of 4.0+/-0.9 GeV, and the corresponding 0.2-300 GeV luminosity is ~1.3*10^36 erg/s at a distance of 12 kpc. There is no radio pulsar in the 3{\sigma} circle responsible for the high {\gamma}-ray luminosity. While the inverse Compton scattering scenario would lead to a difficulty in the electron energy budget, the source emission can naturally be explained by the hadronic interaction between the relativistic protons accelerated by the shock of SNR Kesteven 41 and the adjacent northwestern MC. In this paper, we present a list of Galactic thermal composite SNRs detected at GeV {\gamma}-ray energies by Fermi-LAT is presented

Description of a Sulfitobacter Strain and Its Extracellular Cyclodipeptides

A marine bacterium M44 was separated from 30 m deep seawater in the East China Sea (26° 28.3′ N 122° 29.0′ E) in 2006. 16S rDNA gene sequence comparison showed that the strain M44 was a member of the genus Sulfitobacter and highly similar to KMM 3554T. A series of experiments demonstrated that this strain M44 had many distinctive characteristics: its cells were gram-negative and mesophilic; its colonies were slightly yellowish, round, convex, and smooth; and it could grow at 10–28°C, pH 6.0–10.0, and in the presence of 0–12.5% (w/v) NaCl; the optimum growth conditions were 25°C and pH 7.0, and the optimum Na+ concentration was 2.5%. In addition, strain M44 contained 18 : 1 ω7c, 11 methyl 18 : 1 ω7c and 16 : 0 fatty acids as major fatty acids, and the genomic DNA G+C content was 58.04 mol%. According to our results of the secondary metabolites, six cyclodipeptides were isolated from the strain M44, which were Cyclo (Val-Leu), Cyclo (Phe-Val), Cyclo (Phe-Leu), Cyclo (Leu-Ile), Cyclo (Phe-Ile), and Cyclo (Trp-Pro). It is the first study of secondary metabolites isolated from this genus

Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

SIRT1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. The brain-specific SIRT1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. And the female mice without SIRT1 in POMC neuron are more sensitive to diet-induced obesity. Here we created transgenic mice overexpressing SIRT1 in striatum and hippocampus under the control of CaMKIIα promoter. These mice, especially females, exhibited increased fat accumulation accompanied by significant upregulation of adipogenic genes in white adipose tissue. Glucose tolerance of the mice was also impaired with decreased Glut4 mRNA levels in muscle. Moreover, the SIRT1 overexpressing mice showed decreased energy expenditure, and concomitantly mitochondria-related genes were decreased in muscle. In addition, these mice showed unusual spontaneous physical activity pattern, decreased activity in open field and rotarod performance. Further studies demonstrated that SIRT1 deacetylated IRS-2, and upregulated phosphorylation level of IRS-2 and ERK1/2 in striatum. Meanwhile, the neurotransmitter signaling in striatum and the expression of endocrine hormones in hypothalamus and serum T3, T4 levels were altered. Taken together, our findings demonstrate that SIRT1 in forebrain regulates lipid/glucose metabolism and motor function

Demonstrating anyonic fractional statistics with a six-qubit quantum simulator

Anyons are exotic quasiparticles living in two dimensions that do not fit into the usual categories of fermions and bosons, but obey a new form of fractional statistics. Following a recent proposal [Phys. Rev. Lett. 98, 150404 (2007)], we present an experimental demonstration of the fractional statistics of anyons in the Kitaev spin lattice model using a photonic quantum simulator. We dynamically create the ground state and excited states (which are six-qubit graph states) of the Kitaev model Hamiltonian, and implement the anyonic braiding and fusion operations by single-qubit rotations. A phase shift of $\pi$ related to the anyon braiding is observed, confirming the prediction of the fractional statistics of Abelian 1/2-anyons.Comment: revised version 3, revTex, 4.3 pages, 4 figures, notes and reference adde